GENOSTICS CANCER CONFERENCE - 2018
KNOW YOUR OPTIONS III
13th - 14th October, Four Seasons Hotel, Sydney
This full-weekend conference will outline an integrative approach to clinical diagnostics, treatment and monitoring of cancers, with a particular focus on immune therapies and within the burgeoning paradigm of precision medicine. Discounted early bird registration now open.
Are CTCs ripe for screening?
Tuesday June 3rd, 6pm AEST
Speaker: Prof. Katharina Pachmann
Invasion occurs very early in tumour development. Before a malignant tumour is detectable with standard imaging techniques, a subpopulation of tumour cells may detach from the primary lesion, migrate through the extracelluar matrix and invade the bloodstream. Here, the more aggressive subtypes survive despite annoikis, abrasive forces and attack from the immune system. These cells are called Circulating Tumour Cells (CTCs). CTCs have often downregulated their phenotype and adopted stem-cell features. Heterogenous to cells of the primary cancer, CTCs may be able resistant to treatment of curative intent. This resistance, together with environmental stimulus may trigger the cells to extravase from the bloodstream and proliferate as a metastatic lesion.
CTC count (blood test to look for numbers of CTCs per volume of peripheral blood) is now well established as a prognostic indicator and a tool to monitor treatment effectiveness. The current topic that is taking the research community by storm is whether detection of these cells may be used clinically as a tool for diagnostic screening. Challenges that researchers are up against is the fact that these cells are extremely rare, in comparison to the volume of blood cells. CTCs also often downregulate detectable antigens, meaning they may evade detection. Despite the existence of methods with extremely high sensitivity profiles, the risk of false diagnosis remains. In this webinar, Prof. Katharina Pachmann will be discussing the current status and the future prospective of CTCs as a clinical tool in early diagnostic screening.
This is a practitioner-only event
Reserve your place:
Clinical relevance of target and resistance biomarkers on Circulating Tumour Cells
Tuesday 5th June 2018
Speaker: Dr. Joachim Fluhrer
Circulating Tumour Cells (CTCs) are the haematogenous, metastasising population of cancer cells. Having undergone the Epithelial-Mesenchyme Transition, CTCs have stem-cell-like features that bestow them with powerful proliferative potential. Thus activation and extravasion of these cells can lead to metastasis. Due to cancer's inherent genetic instability, CTCs are heterogenous to cells of the primary tumour. Their enumeration and analysis can offer valuable information about a patient's cancer and individualised metastatic prevention strategies. Downstream analysis of these cells gives clinicians powerful clues as to their likely response to targeted therapies, as well as their potential resistance mechanisms. Some of the biomarkers that will be discussed are:
- ki67: Marker of proliferative capacity. Used in combination with other markers, ki67 can be useful in determining, for example, the proportion of PSA-positive cells with proliferative capacity.
- ER: Metastatic breast cancer patients with ER-positive primary tumours have frequently been shown to have ER-negative CTCs. As a result, these cells are likely to resist endocrine therapy.
- AR: Acquired resistance to first line hormonal therapy in prostate cancer is heterogeneous in the extent of androgen receptor pathway reactivation. Measurement of pre- and post- treatment AR signaling within CTCs may help target such treatments to patients most likely to respond to second line therapies.
- PD-L1 has emerged as a critical inhibitory pathway in regulating T-Cell response. Nevertheless, much of the tumour immune resistance pathways are yet to be elucidated and there is still a high degree of non-responders to treatment. CTCs represent a non-invasive liquid biopsy where the subgroup of non-responders may be identified early.
This is a practitioner-only event. Sign-on is now available:
Cancer and the microbiome
Monday 30th April, 6pm AEST
Speaker: Prof. Luis Vitetta
- The human microbiome
- Bacteria and cancer
- Probiotics as adjuvant treatments
Cancer arises from the acquisition of multiple genetic and epigenetic changes in host cells over the span of many years, promoting oncogenic traits and carcinogenesis. Studies of cancer in mice have long had anecdotal evidence that shifts in the microbiome influence the development of diverse tumour types Mechanisitic evidence is now available to support the posit that that the intestinal microbiota plays a major part in defining both the efficacy and toxicity of chemotherapeutic agents. However, the biological complexity encountered remains a major barrier to further progressing our understanding of mechanisms at work.
The interplay between metastasising cancer cells and immunotherapy
Speaker: Dr. Joachim Fluhrer
- Immune system and inflammation in oncogenomics
- Natural Killer cells in cancer and immunotherapy
- Downregulated CTCs and CTC fragments as markers of immune activity
Monday 26th March 4pm AEST (6pm NZST)
Tuesday 27th March 6pm AEST (8pm NZST)
The resistance mechanisms of tumour cells are now a focus of Oncology research laboratories and clinics across the globe. Despite surgery, chemotherapeutic treatment and ionizing radiation, cancers can spread or relapse, and it is this metastatic progression that is primarily responsible for the majority of cancer-related deaths.
The last decade has seen a burgeoning of research and interest in the harnessing the role of the immune system in the treatment cancer. Both the innate and adaptive immune systems play a critical role in preventing the development of neoplastic disease in a process called 'immunosurveillance.' When the immune system is functioning well, tumour cells are eliminated. When the immune response is inadequate, tumour growth and immunosurveillance enter a tug-of-war until a tumour cell mutates to evade surveillance and proliferates.
Recent advances in understanding the biology of Natural Killer (NK) cells has generated enormous interest in their clinical utility. NK cells possess powerful anti-tumour mechanisms that show great potential in counteracting the a tumour's evasion of the immune system.
Circulating Tumour Cells are the metastasising population of cancer cells that have mutated to allow migration into the bloodstream. The dynamics of these cells as indicators of treatment response and metastatic potential has been repeatedly demonstrated. The most aggressive of these cells are able to evade the immune system and may eventuate in metastatic growth. Knowledge of the immunogenicity of these cells and their interplay with Natural Killer cells represent a new point of conversion between the prevention of tumour progression and immunotherapy.
Detection and relevance of circulating Cancer Stem Cells and Tumour Spheres
Speaker: Dr. Joachim Fluhrer
27th FEB 2018
- Epithelial-Mesenchyme-Transition markers
- Detection of metastases-initiating CTCs
- Clinical utility of circulating Cancer Stem Cells and Tumour Spheres
The identification and characterization of the subset of metastasis-initiating cells among the Circulating Tumour Cell (CTC) population in patients is of paramount clinical importance. The Epithelial-Mesenchymal Transition (EMT) is a process of dedifferentation that sub-populations of cancer cells undergo that render them motile and stem-cell like. Resent research in multiple cancer types have demonstrated that major proportions of CTCs in metastatic cancers display EMT and stem cell properties. These cells were often found to travel in clusters of 2-50 cells, with the ratio of single vs clustered CTCs varying significantly among different patients, and along disease progression. The presence and increasing proportion of CTC clusters, called 'Tumour Sphere Units' in the circulation is associated with poor metastases-free and overall survival.
This webinar details the detection and clinical utility of these circulating cancer cell clusters and their stem-cell-like nature. The webinar is 40 minutes and will include a discussion.
40 minutes including discussion
Saturday 11th & Sunday 12th November, 2017
Four Seasons, SydneyThe seminar focused on currently available options for personalised diagnostics and the effective monitoring of a person's cancer in real time, as well as presented additional treatment strategies that may arise from personalised diagnostics.
Video recording + lecture slides are available for pre-order and will be available soon.
Please note, to ensure patient confidentiality, some lectures/slides will not be distributed.
Price: $95 (+gst)
Monitoring the effectiveness of cancer treatment
A joint-seminar with Dr. Katherina Pachmann and Dr. Fluhrer
Practitioners are invited to join practitioners at the Genostics CTC Seminar designed to bring you the latest information on how to monitor the effectiveness of cancer treatment, presented by world-renowned CTC scientist Prof. Katherina PachmannThe Seminar
Circulating Tumour Cells (CTCs) are the metastasising population of cancer cells. CTCs are now well established as independent prognostic indicators of metastatic disease. CTC enumeration and analysis represents a 'fluid-biopsy,' with results now firmly associated with clinical outcome. Practitioners and Oncologists who are interested or are already benefiting from using CTC-tests will be in attendance.
Prof. Katherina Pachmann is a world-renowned expert in Circulating Tumour Cell science - both in research and in translational medicine. She has worked internationally in academically and scientifically acclaimed cell research centers. She will be presenting new research at COSA and the World Cancer Congress in November in Melbourne, as well as presenting seminars to practitioners in locations around Australia and New Zealand.
Dr. Joachim Fluhrer has recently been acknowledged internationally for Excellence in Integrative Medicine, and will be touring alongside Prof. Pachmann. Dr. Fluhrer brings his clinical and medical expertise to the discussion table, and is passionate about facilitating the best in evidence-based medical research for use in the clinical setting.
This seminar will be a unique opportunity to meet CTC expert scientist Prof. Pachmann and discuss clinical cases you might have with her and Dr. Fluhrer together. The seminar will include updates on the latest in CTC-technology and how it is revolutionising cancer monitoring, and will be a great chance to meet and discuss personalised cancer treatment with colleagues.
More info.. Professor Pachmann has concentrated her research career on the detection, identification, and treatment of cancer cells in the peripheral blood. Professor Pachmann has worked in cell research internationally in academically and scientifically acclaimed centres such as Karolinka Insitute Stockholm, Sweden; Institute of Hematology,GSF Munich, Germany; MD Anderson Cancer Centre Houston, Texas.
Presently Professor Pachmann has her laboratory at the Klinik fur Innere Medizin II Fredrich-Schiller Universitat in Germany, where she holds Professorship Experimental Hematology and Oncology. Professor Pachmann has numerous publications in world renowned journals of Hematology, Clinical Oncology, Surgical Oncology and Cancer Research.
CTC Webinar Series
Presented by Dr Joachim Fluhrer
Level I: (Completed)
Metastatic biology, Circulating Tumour Cells and personalised cancer management
Level II: (Completed)
In the clinic: monitoring treatment effectiveness and metastatic risk, CTC test selection and report interpretation
Level III: (Completed)
Clinical Case Discussions: practitioner presentations